The First To Die At The End Free EPUB By Adam S...
Background: Metastatic triple-negative breast cancer (mTNBC) is incurable. A key treatment goal is providing palliation while maintaining patients' health-related quality of life (HRQoL). IMpassion130 demonstrated progression-free survival benefit with atezolizumab + nab-paclitaxel (A + nP) versus placebo + nab-paclitaxel (Pl + nP) in first-line treatment of mTNBC patients with programmed death-ligand 1 positive (PD-L1+) tumors. We report data on patient-reported outcomes (PROs), which capture patient perspectives of treatment.
The First to Die at the End Free ePUB by Adam S...
Before His own townspeople, in Nazareth, Christ refers to the words of the prophet Isaiah: "The Spirit of the Lord is upon me, because he has anointed me to preach good news to the poor. He has sent me to proclaim release to the captives and recovering of sight to the blind, to set at liberty those who are oppressed, to proclaim the acceptable year of the Lord."19 These phrases, according to Luke, are His first messianic declaration. They are followed by the actions and words known through the Gospel. By these actions and words Christ makes the Father present among men. It is very significant that the people in question are especially the poor, those without means of subsistence, those deprived of their freedom, the blind who cannot see the beauty of creation, those living with broken hearts, or suffering from social injustice, and finally sinners. It is especially for these last that the Messiah becomes a particularly clear sign of God who is love, a sign of the Father. In this visible sign the people of our own time, just like the people then, can see the Father.
The above titles which we attribute to the Mother of God speak of her principally, however, as the Mother of the crucified and risen One; as the One who, having obtained mercy in an exceptional way, in an equally exceptional way "merits" that mercy throughout her earthly life and, particularly, at the foot of the cross of her Son; and finally as the one who, through her hidden and at the same time incomparable sharing in the messianic mission of her Son, was called in a special way to bring close to people that love which He had come to reveal: the love that finds its most concrete expression vis-a-vis the suffering, the poor, those deprived of their own freedom, the blind, the oppressed and sinners, just as Christ spoke of them in the words of the prophecy of Isaiah, first in the synagogue at Nazareth106 and then in response to the question of the messengers of John the Baptist.107
As put by Frederick Douglass, "His own statement, that he had been contemplating a bold strike for the freedom of the slaves for ten years, proves that he had resolved upon his present course long before he, or his sons, ever set foot in Kansas."[98] According to his first biographer James Redpath, "for thirty years, he secretly cherished the idea of being the leader of a servile insurrection: the American Moses, predestined by Omnipotence to lead the servile nations in our Southern States to freedom."[99] An acquaintance said: "As Moses was raised up and chosen of God to deliver the Children of Israel out of Egyptian bondage, ...he was...fully convinced in his own mind that he was to be the instrument in the hands of God to effect the emancipation of the slaves."[100]
As he began recruiting supporters for an attack on slaveholders, Brown was joined by Harriet Tubman, "General Tubman," as he called her.[124] Her knowledge of support networks and resources in the border states of Pennsylvania, Maryland, and Delaware was invaluable to Brown and his planners. Some abolitionists, including Frederick Douglass and William Lloyd Garrison, opposed his tactics, but Brown dreamed of fighting to create a new state for freed slaves and made preparations for military action. After he began the first battle, he believed, slaves would rise up and carry out a rebellion across the South.[125]
Some writers describe Brown as a monomaniacal zealot, others as a hero. In 1931, the United Daughters of the Confederacy and Sons of Confederate Veterans erected a counter-monument, to Heyward Shepherd, a free black man who was the first fatality of the Harpers Ferry raid, claiming without evidence that he was a "representative of Negroes of the neighborhood, who would not take part".[177] By the mid-20th century, some scholars were fairly convinced that Brown was a fanatic and killer, while some African Americans sustained a positive view of him.[178] According to Stephen Oates, "unlike most Americans at his time, he had no racism. He treated blacks equally. ...He was a success, a tremendous success because he was a catalyst of the Civil War. He didn't cause it but he set fire to the fuse that led to the blow up."[179] Journalist Richard Owen Boyer considered Brown "an American who gave his life that millions of other Americans might be free", and others held similarly positive views.[180][181][182]
Two investigators independently screened the title and abstract of each citation identified by the search and subsequently reviewed the full-text manuscript for final inclusion into the review. Discrepancies were resolved by discussion or a third investigator. A study (any design) was included if it (1) evaluated an alternative buprenorphine initiation strategy that aimed to avoid prerequisite opioid withdrawal, (2) was in patients with substance use disorder or chronic pain that were taking a full opioid agonist and (3) reported presence or absence of withdrawal during the initiation phase. Traditional initiation of buprenorphine includes an opioid-free period to establish mild to moderate prerequisite withdrawal, considered to be a minimum score of 5 or more on the Clinical Opiate Withdrawal Scale (COWS) [18,19,20]. Such studies were excluded. We defined alternative strategies aimed to avoid prerequisite withdrawal as those that either (1) overlapped the full opioid agonist and buprenorphine (omitting the opioid free period and thus omitting prerequisite withdrawal) or (2) reported a baseline COWS score of less than 5 (documenting lack of withdrawal symptoms). In the absence of a reported baseline COWS score, we estimated the maximal possible score using symptoms reported prior to the first buprenorphine dose and included reports with a score less than 5. In addition to withdrawal, additional outcomes of interest included severity of withdrawal, number of patients that fully transitioned from full opioid agonist to buprenorphine monotherapy, duration of the initiation period, number of patients with a deviation from the initiation protocol, and patient satisfaction. Post-initiation outcomes included the duration buprenorphine was continued and the number of patients that experienced the following: illicit drug use, overdose, and cravings.
Madame Bovary by French author Gustave Flaubert was originally published in 1857. It was Flaubert's first novel and before it was published in book form, it was serialised in Revue de Paris where it was prosecuted for obscenity. After the trial and acquittal of the author, Madame Bovary became a bestseller. It tells the story of Charles Bovary, who has an arranged marriage with a rich widow, but who falls for Emma Roualt. After his wife dies unexpectedly, Charles marries Emma. In contrast to Charles, Emma is very high maintenance and though her husband does his best to keep her from feeling bored with marriage and motherhood, it doesn't work, and she has two affairs. The first with Rodolphe Boulanger, a wealthy local man who seduces Emma but grows bored of her. The second is Léon Dupuis, a clerk who introduces Emma to poetry and who falls in love with her. But this affair too, ends. All the while, Emma, with her love for luxury goods, has been getting her and her husband into more and more debt, using credit from the manipulative Monsieur Lheureux. The story ends tragically when the debts are called in. 041b061a72